What is the Inverse protein folding problem ?
The inverse folding problem was originally defined by Drexler [1] and Pabo [2] as the problem of defining the sequences compatible with a given protein fold. It is fundamental to protein design and engineering, and, as such, as attracted considerable interest [3-8]. Since the function of a protein is directly related to its three dimensional structure, manipulation of the structure via the sequence changes can provide functional diversity. Protein molecules can be engineered to optimize their activities, as well as to alter their pharmacokinetic properties.
