What is the impact of change in diagnostic test method on surveillance data trends in Chlamydia trachomatis infection?
Burckhardt F; Warner P; Young H Bavarian Health and Food Safety Authority (Public Health), Veterinaerstr. 2, 85764 Oberschleissheim, Germany. florian@burckhardt.de OBJECTIVE: To describe the impact of change from culture to more sensitive nucleic acid amplification testing (NAAT) tests on the detection of Chlamydia trachomatis in a genitourinary medicine (GUM) clinic population. METHODS: Data were collected between January 1992 and December 2003 on results of C trachomatis tests on male and female attenders at the Lothian GUM clinic (n = 81 590). Routine diagnosis switched from culture to NAAT methods in September 1998. Association of test result with age, sex, year of test, and test type was analysed using logistic regression. RESULTS: 6.1% (95% CI: 5.7% to 6.5%) of women and 7.1% of men (95% CI: 6.7% to 7.5%) tested positive with culture and 9.9% of women (95% CI: 9.4% to 10.3%) and 11.1% of men (95% CI: 10.7% to 11.5%) tested positive with NAATs. This corresponds to a 56% increase f
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