What is the free T4 by dialysis test used for?
The FT4 by dialysis test is indicated to better identify animals that are euthyroid but whose total- or standard free- T4 is falsely increased due to T4 antibodies or physiologically decreased due to general/systemic illness. A dialysis step first filters out the large antibodies and hormone binding proteins to provide a measurement technique unaffected by antibodies or by changes in T4-protein binding which can occur during non-thyroidal illness. FT4d is useful in cases were total- or standard free- T4 is borderline low and TSH is normal to assist in the differentiation of euthyroid but sick dogs from those 15% of hypothyroid dogs which could have a normal TSH result. FT4 by dialysis may rarely be increased in systemic illness due to decreased protein binding affinity for T4. FT4d is less commonly suppressed by non-thyroidal illness, but does occasionally fall below the reference range in some sick but euthyroid animals. An important point to recognize is that results from both types
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