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What is the factors culminating in the first visible signs – WRINKLES?!

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What is the factors culminating in the first visible signs – WRINKLES?!

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Basically, two types of factors are responsible for skn aging. First, the multiple stresses (pollution, sunlight and physical or psychological stress among others) which cause premature aging of the skin. Secondly, endogenous causes inherent in complex biological factors and mechanisms among them the inability of cells to synthesize the vital components of connective tissue, resulting in programmed againg of the skin.

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