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What is the expected frequency of eight SNPs occurring in the coding region of a single, 1,300 bp ORF?

April 26, 2017BP coding Frequency ORF region SNPs

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What is the expected frequency of eight SNPs occurring in the coding region of a single, 1,300 bp ORF?

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The frequency of multiple SNPs is estimated to be two exonic SNPs per gene (coding and untranslated regions). A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms is located online. Suggestions for verifying your variations: Sequence cDNA products from several independent PCR reactions or test multiple clones. Use a different cell line for the control reaction.