What is the effect of having allele frequencies not add up to 1, eg. when some alleles are not present in a pedigree under study?
[Ellen Wijsman;16may94] Best approach is to specify n+1 alleles, where there are n alleles actually observed in the pedigree. Use the correct allele frequencies for the n alleles, and for the n+1th allele, use 1 minus the sum of the frequencies of the observed alleles. • I use LINKAGE and/or FASTLINK. What references should I cite in my papers? FASTLINK: As described in the papers: R. W. Cottingham Jr., R. M. Idury, and A. A. Schaffer, Faster Sequential Genetic Linkage Computations, American Journal of Human Genetics, 53(1993), pp. 252-263. and A. A. Schaffer, S. K. Gupta, K. Shriram, and R. W. Cottingham, Jr., Avoiding Recomputation in Genetic Linkage Analysis, Human Heredity, to appear. [NOTE, this has appeared, so get the correct reference from the current linkage distribution–rootd] In addition, all fastlink users should also cite the LINKAGE papers: G. M. Lathrop, J.-M. Lalouel, C. Julier, and J. Ott, Strategies for Multilocus Analysis in Humans, PNAS 81(1984), pp. 3443-3446. G.
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