What is the effect of furosemide on tenofovir?
Dr Fine: I have not heard of any direct effect though they both use the organic anion transporter, OAT1, at the apical membrane of the proximal tubule. I have not seen any data that suggest competition at that site, but I am not sure it has been studied. The main concern would be that of overdiuresis with compromise in glomerular filtration rate (GFR), which would then predispose to tenofovir toxicity. • Is urine microalbumin okay to use for proteinuria screening? Dr Fine: Yes, as long as it is an albumin:creatinine ratio (usually it is reported as such) and not just albumin concentration. • We have seen 3 cases of renal-cell cancer in our HIV patients. Have there been any reports of renal-cell carcinoma associated with HIV infection? Dr Fine: I have not heard of this but found this reference: Baynham SA et al, AIDS Patient Care STDS, 1997. Most renal-cell carcinomas are found incidentally these days. One wonders if we are just imaging HIV patients more often and therefore finding more
