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What is the difference in what medication/drugs a pilot can take before flying vs. what a truck driver can take?

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What is the difference in what medication/drugs a pilot can take before flying vs. what a truck driver can take?

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Pilots are not allowed to take illicit drugs or legal drugs for which the labels read, “Do not operate heavy machinery while using this drug”. Conversely, drug drivers have an exception to their regulation, saying that when they are taking prescription drugs with warning labels they can get an exception from the prescribing practitioner and still operate their trucks while under the influence of narcotics, sedatives, pain killers, etc.

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