What is the difference between the action of ZYBRESTAT (fosbretabulin) and anti-angiogenesis drugs?
Fosbretabulin causes the vascular structure inside a solid tumor to collapse, depriving the tumor of blood and oxygen that it needs to survive. Anti-angiogenesis drugs attempt to keep new blood vessels from forming. They do not act on blood vessels that already feed existing tumors. Can I see the effects of ZYBRESTAT in animal studies? Voice Script from Video: This movie was supplied by the Tumour Microcirculation and Advanced Technology Development Groups at the Gray Cancer Institute, Mount Vernon Hospital, Northwood, UK. (http://www.gci.ac.uk) With special thanks to Gill Tozer, Boris Vojnovic and Ian Wilson. Combretastatin A4-P as a tumor vascular targeting agent. This is a tumor viewed under the microscope. A large blood vessel can be seen running across the surface of the tumor. This vessel is draining the waste products from the tumor tissue. At high magnification, you can see the individual red blood cells flowing through the vessels. Generally, the blood flow is moving very fast
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