What is the difference between small domain sites and large clinical sites?
The size of a proposed site relates to the intended goal of this site. Small sites might consider focusing exclusively on psychometric development of new domains. Other small sites may want to conduct some initial validation of these new domains, or further study of domains already in the PROMIS network, in appropriate, enriched patient populations. Large sites could propose to develop new domains, or further evaluate existing PROMIS domains in large scale clinical validation studies similar in size and scope to NIH phase III clinical trials that are intended to change patient care.
