What is the difference between PepGen P-15 and Emdogain®?
Emdogain consists of resorbable enamel matrix proteins of porcine origin. It is applied to the root surface of teeth and claims to form root cementum while preventing the downgrowth of a long junctional epithelium. Emdogain provides only an organic component despite the fact that autogenous bone is composed of both organic and inorganic components. Emdogain claims 36% defect fill in 36 months. PepGen P-15 is a synthetic composite of porous hydroxyapatite and a peptide that mimics the cell-binding portion of Type I collagen. PepGen P-15 promotes the attachment of reparative cells and is directed toward bone regeneration. PepGen P-15 provides both the organic and inorganic component and thus mimics autogenous bone. PepGen P-15 has demonstrated 72% defect fill in 6 months.
