What is the difference between pemphigus and pemphigoid?
Both are blistering disorders caused by autoimmune problems that result in an attack on the skin cells by the individual’s own antibodies. The attack may occur at various layers of the skin. Pemphigus causes a cleavage within the epidermis (top layer of the skin), and the blisters are flaccid and break easily. Pemphigoid produces a split below the epidermis, causing deeper, tense blisters. Pemphigoid is seen most often in the elderly. Both are treated with similar medications. Severe cases may require different treatment. Either condition may remit after a period of time.
