What is the difference between ISAS using SPM and BioImage Suite?
ISAS BioImage Suite provides a custom user interface for the analysis and eliminates any compatibility problems between different versions of MATLAB and SPM2. In addition, the registration algorithm in BioImage Suite has been shown to perform better on multimodal neuroimaging data when compared to the algorithm used by SPM2. The quality registration into common space is critical in the prevention of skull artifacts in the analysis. However, ISAS for both BioImage Suite and SPM follow the same processing step and should provide similar results for most studies.