What is the difference between atelocollagen and collagen?
In a Type I collagen molecule, there are antigenic formations called “telopeptides” at each end of the protein. A telopeptide extremity in a collagen molecule consists of about 12-27 amino acids. The peptide sequence in a telopeptide is unique to each individual; and, complete removal of the peptide is necessary to avoid an immune reaction. Atelocollagen is a telopeptide-free collagen that is non-immunogenic. An atelocollagen molecule has a complete triple helical alpha-chain structure consisting of about 1010 amino acids.
