What is the difference between a significant change and a minor change to an ACUP?
Significant changes to an ACUP require that the proposal be amended by submitting an addendum for IACUC review and approval. Examples of significant changes include changes in study procedures or design, addition of new surgical procedures, use of new drugs or treatments, changes in personnel, changes in approved method of euthanasia, changes in animal species, or increasing the number of authorized animals. Examples of minor changes that do not need an addendum include, changes in animal weight or age requirements, reduction in the dosage of approved drugs, reduction in the frequency of study related procedures other than husbandry, reduction in animal numbers and minor variations in the schedule of previously approved procedures.
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