What is the difference between a significant and minor change to a protocol?
Minor changes can include (but are not limited to): a change from jugular vein to tail vein for obtaining a blood sample, or change in anesthetic agent. Significant changes can include, (but are not limited to): PI change, change in objective, switch from non-survival to survival surgery, change of species, withholding of analgesics, any increase in degree of invasiveness of a procedure or discomfort to an animal. Ask the Office of Compliance if you are unsure if your change is minor or significant. If you need additional information, contact the Compliance Officer at 494-8918 or you can send an e-mail.
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