What is the difference between a restriction fragment length polymorphism (RFLP) and a single nucleotide polymorphism (SNP)?
When you talk about DNA spelling differences, it’s just one common thing-how the DNA sequence varies between people. But the way that you test for that DNA spelling difference depends on the tools you have in your laboratory. Twenty years ago the only way that we could test for a spelling difference was to try to cut the DNA with a restriction enzyme and either it would cut or it wouldn’t cut. That made a restriction fragment length polymorphism, but that was just a technical detail of how you tell if the spelling difference was one or the other. So when you talk about RFLPs and microsatellites and this and that, they’re all just different ways of [describing] DNA spelling differences. DNA polymorphisms let us track the inheritance of chromosomes in families and in whole populations. Can you describe the term bioinformatics and explain what it has meant to the field of biology? The whole intellectual enterprise of writing analysis tools–computer tools–that analyze biological data goe
When you talk about DNA spelling differences, it’s just one common thing-how the DNA sequence varies between people. But the way that you test for that DNA spelling difference depends on the tools you have in your laboratory. Twenty years ago the only way that we could test for a spelling difference was to try to cut the DNA with a restriction enzyme and either it would cut or it wouldn’t cut. That made a restriction fragment length polymorphism, but that was just a technical detail of how you tell if the spelling difference was one or the other. So when you talk about RFLPs and microsatellites and this and that, they’re all just different ways of [describing] DNA spelling differences. DNA polymorphisms let us track the inheritance of chromosomes in families and in whole populations. Can you describe the term bioinformatics and explain what it has meant to the field of biology? The whole intellectual enterprise of writing analysis tools–computer tools–that analyze biological data goe
