What is the current position with respect to the use of No Observed Effect Concentrations in the CHARM model?
NOEC values can be used in the determination of Predicted No Effect Concentrations (PNECs). As indicated in table 2 of the CHARM manual. It should be noted that a no observed effect concentration (NOEC) result reflects lowest concentration that was actually tested and found to have no effect during a toxicity test. In line with EU technical guidance, NOEC values are only acceptable if derived from internationally recognised chronic test procedures. Chronic tests are generally those that cover a significant period or test organism’s lifecycle and for which the NOEC is based on a non-lethal endpoint. The algal test is included in this definition as are the fish juvenile growth test OECD 215 and Daphnia reproduction test OECD 211.
