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What is the correlation between mRNA and protein knockdown?

April 26, 2017correlation knockdown mrna protein

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What is the correlation between mRNA and protein knockdown?

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Generally, mRNA and protein roughly correlate with one another in a functional genomics experiment. That said, many times the efficacy/potency of silencing can differ between the mRNA and protein levels. Also, the half-life of the protein is generally much longer than that of its corresponding transcript. Protein knockdown is very dependant on the protein being studied.