What is the connection between insulin resistance and PCOS?
At least 30 percent of women with PCOS are insulin resistant, although some investigators claim a much stronger association exists. Hyperinsulinaemia as explained above works selectively on the ovaries and stimulates them to produce more androgen or male hormones. It also reduces the binding of the free androgen thereby creating an environment where plenty of free male hormones are circulating the blood and in the local tissues of the ovary. This forms the starting point for formation of poly cystic ovaries and ultimately leading to the syndrome.
At least 30 percent of women with PCOS are insulin resistant, although some investigators claim a much stronger association exists. Hyperinsulinemia produces hyperandrogenism by stimulating ovarian androgen production and by reducing serum sex-hormone binding globulin (SHBG). This can heighten PCOS symptoms. Reducing insulin resistance through the use of insulin-sensitizing medications can restore ovulatory function in many women with PCOS. It appears that even some patients who do not test as being insulin resistant may benefit from these medications.
