What is the cause of subcorneal pustular dermatosis?
The cause of subcorneal pustular dermatosis is not known. However, it is associated with some other conditions. The most frequent are: • IgA monoclonal gammopathy (accumulation of abnormal proteins in the blood) • Multiple myeloma • Pyoderma gangrenosum. Other less frequent associated conditions include rheumatoid arthritis, lupus erythematosus, hyperthyroidism and hypothyroidism, polycythemia rubra vera, and SAPHO syndrome (synovitis, acne, pustulosis, osteitis). Subcorneal pustular dermatosis can be very difficult to distinguish from generalised pustular psoriasis and acute generalised exanthematous pustulosis. They appear to be closely related disorders.
