What is the cause of narcolepsy in subjects with normal hypocretin levels or with strong tendency to have narcolepsy running in their family?
We look at the hypocretin genes of many cases who had a strong family history and found no mutations. Other genes and systems must be involved. What is the role of hypocretins in regulating normal sleep? Some results suggest a role of hypocretins in regulating appetite and general body energy. We need to better understand the connection between sleep, energy metabolism, feeding and hypocretins in narcolepsy. TalkAboutSleep: Thank you, Dr. Mignot, for your comments. We look forward to more breakthroughs from your team in the future.
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