What is the case that MCS is a toxicological phenomenon?
Dr. Pall: Cases of MCS are reported to be initiated by seven classes of chemicals. • The organic solvents and related compounds; • Three classes of pesticides (organophosphorus/carbamate pesticides, pyrethroid pesticides, and organochlorine pesticides); • Mercury; • Hydrogen sulfide; • And carbon monoxide. (Some organic mercurials may act like mercury.) Members of each of these seven classes of chemicals are known to be able to produce substantial increases in NMDA activity in the mammalian body. [NMDA is an “excitotoxin” – a substance that causes nerve cell damage.] Furthermore, one can lower the toxic responses to members of each of these seven classes of chemicals by using an NMDA antagonist. This tells us that not only does the NMDA increase occur, but it is an important part – probably the dominant part – of the toxic response in the body to each of these seven classes of chemicals. So we have a common response to all of these diverse chemicals that may explain how these chemicals
