What is the BUD for extemporaneously compounded eye drops for both inpatient and outpatient use?
The BUD of ophthalmic CSPs depends on the microbial contamination risk level of the compounding process, i.e., whether that for Immediate-Use CSPs, Low-Risk Level CSPs with 12-Hour or Less BUD, Low-Risk Level CSPs, Medium-Risk Level CSPs, or High-Risk Level CSPs. 29. If a commercially available IV fluid (i.e., Lactated Ringers or Normal Saline) is spiked in anticipation of emergent administration, for example in an ambulance, trauma emergency bay or a trauma OR room, does the 1 hour expiration time apply to this situation? No. Since the spiking of an IV bag is not considered sterile compounding, the one hour time limit would not be applicable. The individual performing this task should use appropriate technique and should perform (if possible) a thorough hand sanitization.
