What is the better formulation of microencapsulated potassium chloride?
Author(s): Simoneau G, Bergmann JF, Pamphile R, Caulin C, Segrestaa JM Affiliation(s): Clinique Therapeutique, Hopital Lariboisiere, Paris, France. Publication date & source: 1994-01, Eur J Drug Metab Pharmacokinet., 19(1):71-5. Publication type: Clinical Trial; Randomized Controlled Trial A single blind cross-over study was performed comparing a new microencapsulated potassium chloride tablet (MET) with two reference formulations of oral potassium, namely potassium chloride solution (PS), and microencapsulated potassium chloride capsules (MEC), in 18 normal healthy volunteers. The potassium chloride induced change in gastric potential difference (PD) of the mucosa was the main criterion of comparison and was assessed by the area above curve (AAC), the total duration of the effect (TDE), the maximal variation of PD (delta MAX), and the aggression index (AI). The results showed that all three formulations induced a fall in PD; the delta MAX and AAC were significantly greater for PS indi
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