What is the best/most powerful gun in Fallout 3?
As Ed stated, the Experimental MIRV is easily the most powerful weapon in Fallout 3 in terms of sheer destructive power. But I wouldn’t call it the best weapon simply because it weighs too much, is too dangerous to use and because Mini Nukes are hard to come by. It should only really be used on Super Mutant Behemoths. The Alien Blaster on the other hand only weighs two units, comes with over 100 shots right when you pick it up, and can take down most of the enemies in the game with only one shot even with a low skill rating in Energy Weapons. As long as you don’t use it on every single enemy in the game and are able to find some extra ammo for it, the Alien Blaster can last you for pretty much the entire game.
