What is the best dosage for Metformin and Gliclazide after?
Metformin MOA: reduces hepatic glucose production, increases peripheral utilization of glucose. Metformin affects blood glucose concentrations and may alter the control of Type I diabetes or increase risk of hypoglycaemia when used with other antidiabetic agents. Metformin is not routinely indicated for Type I diabetes. The major concern is metabolic acidosis, and metformin is contraindicated where ketoacidosis is an ongoing concern, and in metabolic acidosis or catabolic states. These states are possible outcomes of poorly controlled Type I diabetes. http://care.diabetesjournals.org/cgi/content/full/26/1/138 A few reports of metformin added to insulin therapy in type 1 diabetic adults documented that the subjects showed a reduction in insulin requirements and variable changes in glycemic control (17–19). Preliminary results of two studies of metformin use in teens with type 1 diabetes have yielded conflicting results (20,21). No studies have measured physiological changes in SI in res
