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What is the basis for the recommendation that LAIV should only be given to healthy person up through 49 years of age?

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What is the basis for the recommendation that LAIV should only be given to healthy person up through 49 years of age?

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LAIV is only recommended for healthy, nonpregnant persons 5 years through 49 years of age because this is the population in which the clinical trials were conducted. FDA licensed the vaccine for use based on the manufacturer’s clinical trials data. There are no ACIP off-label recommendations to administer LAIV to any other age groups.

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