What is the approximate bioequivalence of DORMOSEDAN GEL as compared to IM and IV administered DORMOSEDAN sterile solution?
The entire contents of a DORMOSEDAN GEL syringe contain approx. 22 mg of detomidine hydrochloride. This is comparable to 2.2 ml of DORMOSEDAN sterile solution. When the 40 μg/kg gel dose is administered to a horse sublingually the reduced bioavailability of the gel formulation as compared to the injectable given is approximately equivalent to a 30 μg/kg dose (1.5 ml IM to an average sized horse) or to a horse administered IV detomidine at 10-15 μg/kg (.5 to .75 ml IV to an average sized horse). Please realize this is only a rough approximation for illustrative purposes only, as each horse which is sedated with detomidine will vary based on its temperament, the level of excitement prior to sedation and with its surroundings and the nature of the procedure being performed.
Related Questions
- Can DORMOSEDAN GEL be used to initially sedate a horse and then can DORMOSEDAN sterile solution be administered as a ‘rescue’ sedative to prolong (or deepen) the effect?
- Where should DORMOSEDAN GEL be administered to the horse to be given properly?
- How should vesicants be administered: IV push or short infusion?
