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What is the advantage of an assay for anti-phospholipid antibody cofactors over an assay for the antibody itself?

April 26, 2017advantage anti-phospholipid Antibody assay cofactors

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What is the advantage of an assay for anti-phospholipid antibody cofactors over an assay for the antibody itself?

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Binding of b2GPI to the microwell surface in an ELISA assay may produce a neoepitope similar to that when combined with a phospholipid; assay results with this system show a good correlation with the APS. The serologic detection of anti-b2GPI antibodies provides enhanced clinical sensitivity for thrombosis.