WHAT IS THE ACTIVE COMPONENT IN ABSINTHE?
This issue is not entirely resolved. Alcohol is definitely one main component. However, another candidate is the monoterpene, thujone, which which is considered a convulsant. Thujone’s mechanism of action is not known, although structural similarities between thujone and tetrahydrocannabinol (the active component in marijuana) have led some to hypothesize that both substances have the same site of action in the brain. Thujone makes up 40 to 90% (by weight) of the essence of wormwood, from which absinthe is made (2). Thus, thujone would appear to be a good candidate for a second active component in absinthe. Indeed, thujone has long been considered to be the neurotoxic cause of absinthism. However, the direct evidence to support this idea is scant. Absinthe is 75% alcohol. Therefore, alcohol’s effects will limit the amount of thujone one can ingest. Quite simply, you can only drink a moderate amount of absinthe before you become very drunk from the alcohol. Thujone would have to be acti
