What is Tempostatin and how does it treat disease at the tissue level?
Tempostatin is a small molecule that has been identified by Collgard as influencing a “master switch” in the tissue repair process. This process reflects interactions between the cells in a tissue and the protein support scaffold that binds the cells together – the extra-cellular matrix (ECM). In the setting of tissue injury or damage, Tempostatin acts as a potent and selective inhibitor of stromal cells activation, migration and proliferation and limits the excessive production of collagen type I, thereby preventing the expansion of the extra-cellular matrix. Thus, it exerts selective control of key elements in the common and fundamental process of tissue repair, offering great promise for treating a variety of diseases that share a common feature of progressive changes in tissue structure.
