What is special about the zodiacal constellations?
During the course of the year, the sun seems to pass in front of them as we orbit the sun. Each of the planets are always in front of one of the constellations, as is the moon. That is what makes them significant. Some of the zodiacal constellations are not particularly special in themselves and not very bright, like Aries for example. Leo is probably the best of them from the perspective of observing as it is a lot brighter. Virgo is large and has some nice galaxies visible in it. There are 88 designated constellations in total and many of them are more interesting to observe than the 12 zodiacal ones.
