What is sign for progressive of colorectal carcinoma?
The process of tumor invasion and metastasis is associated with alterations in the functions of several adhesion molecules. In general, tumor cells lose their capacity for normal adherence, which facilitates their detachment from their site of origin. alpha-catenin links E-cadherin to the actin cytoskeleton via its association with either beta- or gamma-catenin. Reduced alpha-catenin expression was associated with tumor invasion and metastases in colorectal cancer (CRC). A research article to be published on August 21, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Adam Elzagheid from University of Turku of Finland examined alpha-catenin expression in a series of 91 patients with advanced colorectal carcinoma, and analyzed the relationship with clinical and pathological features of CRC patients. Archival tumor samples were analyzed using immunohistochemistry (IHC) for alpha-catenin in 91 patients with advanced CRC. Patients with high
