What is p16INK4a?
p16INK4a is a cyclin-dependent kinase inhibitor. This protein plays a crucial role in the retinoblastoma protein (pRB)-mediated control of the G1-S-phase transition of the cell cycle. Loss of p16INK4a expression or a functional inactivation of p16INK4a has been shown in many tumor entities. In contrast, for some cancer entities including cervical cancer, a strong over-expression of p16INK4a has been reported.
Related Questions
- Are there differences in the staining pattern of p16INK4a in dysplastic or neoplastic cells where the HPV genome is episomal in contrast to cells where the HPV-DNA is integrated into the chromosomal DNA of the host cells?
- What is the functional role and the mechanism of induction of p16INK4a and ARF during aging?
- How does detecting p16INK4a differ from detecting Ki67?
