What is Nephrogenic Systemic Fibrosis (NSF)?
Nephrogenic Systemic Fibrosis (NSF) was first described in the medical literature in 2000, though the first case was identified in 1997. The cause of NSF is not known, though it is believed to only occur in patients with severe kidney disease and is linked to the MRI contrast dye, gadolinium. NSF causes fibrosis of the skin and connective tissues throughout the body, causing a thickening of the skin which leads to severely decreased mobility of joints. NSF usually starts in the lower extremities and can also develop in the diaphragm, muscles in the thigh and lower abdomen, and lung vessels. Over time, NSF becomes worse and can cause death. There is no known cure.
