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What is “mixed chimerism” and how does it relate to mini stem-cell transplants?

April 26, 2017mini relate transplants

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What is “mixed chimerism” and how does it relate to mini stem-cell transplants?

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Chimerism is a condition where cells in an organism come from two different individuals. The end result of a blood or marrow transplant is that blood and marrow cells come the donor, while all other types of cells come from the patient. The term “full” chimerism means that all blood and marrow cells in the patient came from the donor. The term “mixed” chimerism means that some cells came from the donor and some came from the patient. After a transplant, the change from patient blood and marrow cells to donor cells does not occur all at once. This change occurs more slowly after a mini or non-myeloablative stem-cell transplant as compared to a myeloablative transplant. With both types of transplant, the immune cells of the donor help this change to occur. For more information, go to: • http://www.mssm.edu/tcf/archives/symposiumxviii/abstracts/1110004a_h_abs.shtml • mmserver.cjp.com/gems/bbmt/328.