What is Methylation Detection?
DNA methylation occurs at CpG sites, which are DNA sequences in which cytosine lies next to guanine. Methylation is mediated by an enzyme (DNA methyltransferase). CpG sites are rare in an eukaryotic genome, except in regions near the promoter of a eukaryotic gene. These regions are known as CpG islands, and the state of methylaiton at these CpG sites is critical for gene activity / expression.
