What is meant by the option force include coding non-synonymous SNPs?
Coding non-synonymous SNPs are the variations in the gene that bring about a change in the amino acid sequence of the resulting protein. Because of their obvious functional implications, they are excellent candidates for conferring susceptibility to disease. Thus, one may want to include such SNPs in a study, irrespective of whether or not they are selected as tagSNPs. Therefore, we have provided the option in QuickSNP to “force include coding non-synonymous SNPs,” which will result in a list of SNPs comprising the tagSNPs as well as the coding non-synonymous SNPs in the user-specified region. We have a whole genome coding non-synonymous SNP database linked to the server, which will automatically generate these SNPs for the gene(s) or region specified. The user need not manually extract coding non-synonymous SNPs to use this option.
