What is in the Drug Interactions section of Epocrates drug monographs?
The Drug Interactions section of Epocrates Rx monographs includes identified and evidence-based theoretical interactions that are both pharmacokinetic and pharmacodynamic in nature, with the exception of those based primarily on intended therapeutic effects (e.g., using multiple antihypertensive agents in combination). Epocrates medical information editors go far beyond the prescribing information when researching drug interactions, often extrapolating broad statements involving mechanisms, such as cytochrome P-450 (CYP), P-glycoprotein (P-gp), and pharmacodynamic activity, and extending them to carefully researched lists that are maintained to help us track metabolic and clinical effects, taking into account such attributes as inhibition potency, substrate exclusivity, and therapeutic index when determining clinical significance. Drug Interactions are organized according to clinical management (action required by the clinician) and utilize such categories as “Contraindicated”, “Avoid/
