What is HIV-1 drug resistance testing?
This involves analysing the sequence of a portion of the HIV-1 genome which indicates resistance against anti-retroviral treatment. HIV-1 genotyping deciphers the viral genetic material and identifies potential resistance of the virus against anti-retroviral drugs such as Protease Inhibitors or Reverse Transcriptase (RT) Inhibitors, Nucleoside and Nucleotide RT Inhibitors. The HIV-1 genotype of an infected individual reflects the presence or absence of mutations in viral RNA associated with anti-retroviral resistance. All newly-diagnosed patients with HIV-1 infection are now recommended to have genotypic resistance analysis prior to the commencement of therapy. HIV drug resistance testing is not intended to be used as a screening test for HIV or as a diagnostic test to confirm the presence of HIV infection. Used in conjunction with clinical presentation, laboratory markers, and antiretroviral history as an adjunct to the therapeutic management of patients with HIV-1, subtype B, and a m
