What is historical life expectancy following initial diagnosis?
Each ACC case is unique. The location, stage, histology, treatment protocols followed and individual biology all factor into disease progression and longevity. There are cases of complete control of primary tumor sites with no metastases lasting many years. There are also cases of rapid progression and aggressive metastatic behavior. In a study of 160 ACC patients followed from 1977 through 1996, disease specific survival was 89% at 5 years, but less than 40% at 15 years (Fordice). Improved diagnoses and treatments since that study may have improved patient outcomes, though not substantially.
