What is histamine-mediated angioedema?
Angioedema is frequently seen in association with urticaria allergic reactions. Very typically, the swelling is accompanied by the development of wheals and pruritus (itching). During a urticaria or an allergic reaction, the body releases a protein known as histamine. Among its many actions, histamine acts to temporarily increase the permeability of the vascular walls, allowing increased amounts of fluid to escape from the blood vessels and enter the surrounding tissues. This results in swelling. This type of angioedema is therefore described as histamine-mediated angioedema.
