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What is hereditary leiomyomatosis and renal cell cancer?

April 26, 2017cancer CELL hereditary renal

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What is hereditary leiomyomatosis and renal cell cancer?

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Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a hereditary condition associated with multiple leiomyomas (fibroid skin tumors), uterine fibroids (non-cancerous growths in a woman’s uterus), and type 2 papillary renal (kidney) cancer. A person with HLRCC can have a few skin tumors or many skin tumors. These skin tumors generally develop in adulthood and occur on the chest, back, arms, and legs; the tumors can be painful, but they are not cancerous. Women with HLRCC can develop uterine fibroids as young as their teens or early 20s. What causes HLRCC? HLRCC is a genetic condition. This means that the risk of cancer and other features of HLRCC can be passed from generation to generation in a family. A specific gene called the fumarate hydratase (FH) gene is believed to cause most cases of HLRCC. Research is ongoing to learn more about this condition. How is HLRCC inherited? Normally, every cell has two copies of each gene: one inherited from the mother and one inherited from t