What is Hereditary Fructose Intolerance (HFI)?
Hereditary fructose intolerance (HFI) is a rare genetic disease in which fructose can’t be properly metabolised in the body. Affected person gets bad abdominal reaction (bloating, diarrhea, generalized malaise) after eating fructose-containing foods. HFI is an autosomal recessive disorder of fructose metabolism, due to a deficiency of fructose-1-phosphate aldolase – an enzyme, which converts fructose into glucose in the liver. Incidence of HFI is estimated at 1 / 22-58,000 (1). HFI should be differed from fructose malabsorption.
