What is Gotu kola (Centella asiatica Linn.) and Total Triterpenic Fraction of Centella asiatica (TTFCA)?
The most popular use of gotu kola in the United States is the treatment for varicose veins or cellulitis. Preliminary evidence suggests short-term efficacy (6-12 months) of the total triterpenic fraction of Centella asiatica (TTFCA) in the treatment of “chronic venous insufficiency” (a syndrome characterized by lower extremity edema, varicosities, pain, pruritis, atrophic skin changes, and ulcerations, possibly due to venous valvular incompetence or a post-thrombotic syndrome). Small to moderate benefits on subjective and objective endpoints have been reported. However, the available human trials have been small, methodologically flawed, and employed varying dosages. Many have been published by the same group of investigators. Although this evidence is sufficient to suggest efficacy, further research is necessary before a strong recommendation can be made. No other uses of gotu kola are supported by scientific evidence. Note: Gotu kola is not related to the kola nut ( Cola nitida , Col
