What is Gorhams disease?
Gorham’s disease is a rare musculoskeletal condition in which spontaneous, progressive resorption of the bone occurs. It is known variously as massive osteolysis, disappearing bone, or vanishing bone disease. Although described long ago, this rare and potentially catastrophic disease remains understudied, thus, poorly understood. It is thought to be closely related to, or even a severe form of, lymphangiomatosis. It may be characterized by a proliferation of thin-walled vascular capillaries or lymphatic vessels that starts within the bone. As these vessels proliferate, they aggressively invade the adjacent bone leading to resorption and replacement of angiomatous tissue. The cause remains unknown and it is not usually recognized by clinicians until a fracture occurs, with subsequent improper bone healing. Gorham’s disease is extremely rare and may occur at any age. It is most often recognized in children and young adults, without gender, race predilection, or inheritance pattern. Becau
