What is Genome@Home and how does it relate to the Folding@Home project and the science of Folding@Home?
Genome@Home is another distributed computing project also from the Pande Lab. You can find more details at http://genomeathome.stanford.edu, but briefly Genome@Home’s goal is protein design and its applications. One central application of ours for protein design is the creation of large libraries of designed protein sequences, in a sense “redesigning” or “reverse-engineering” an existing Genome (hence the name “Genome@Home”). Another application of protein design is to understand why proteins fold and why they misfold and aggregate. This is a central question of Folding@Home and directly relates to our study of protein folding and misfolding, as it is related to misfolding-related diseases, such as Alzheimer’s, ALS, etc.
