What is Familial Hypereosinophila?
Marked blood eosinophilia has been seen in a few families in which genetic abnormalities on chromosome 5 have been found. In these cases there have not been any damage to the organs. In some of these patients after many years, of high eosinophil counts, some will go on to develop end organ damage. In most cases of high blood eosinophil counts, the condition is not transmitted to any other family member. The cause for this is unknown but it is thought to be an acquired damage to the genetic makeup of the individual. Return • Tell me more about Idiopathic hypereosinophilic syndrome (HES). The idiopathic hypereosinophilic syndrome by definition excludes all cases of eosinophilia in which a cause can be found for the eosinophilia. Once clonal and reactive eosinophilic disorders are excluded, patients with prolonged eosinophilia must also have evidence of organ damage . Patients who do not have end-organ damage do, have HES, but will need continued regular search for the presence of end-org
