What is EPA doing to reduce both its reliance on default options and the uncertainties that, to date, have been inherent in human health risk assessment?
EPA began revising the 1986 cancer guidelines in light of significant advances in our understanding of the processes of carcinogenesis and the modes of action of disease at the cellular level. Some of the work in these areas that led to advances is the result of EPA research efforts over the past several years. Because our understanding of carcinogenicity, causation of disease, and effects on susceptible lifestages and populations are constantly and quickly evolving, EPA intends to continue research work in this area, as well as collaborate with other research organizations to produce research that ultimately serves to reduce both uncertainties in cancer risk assessments and reduce EPA’s reliance on default options.
